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KMID : 0861020080230020059
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Korea Journal of Herbology
2008 Volume.23 No. 2 p.59 ~ p.65
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Inhibitory Studies of Hwangryunhaedok-tang on Development of Atopic Dermatitis in NC/Nga Mice
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Kim Bo-Ae
Park Ji-Ha
Park Chan-Ik
Kim Mi-So
Kang Bo-Mi
Byeon Seon-Hui
Park Il-Hyang
Jung Ji-Wook
Ahn Eun-Mi
Jung Hyeon-A
Jang Jung-Hee
Bae Won
LEE Ha-Young
Choi Phil-Nye
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Abstract
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Objectives: HRHDT has been known as a useful prescription with antibiotic, anti-inflammatory, antioxidative and immunosuppressive activity. To evaluate anti-atopic dermatitis effect of HRHDT, we treated HRHDT in NC/Nga mice model skin induced contact hypersensitivity.
Methods: Contact hypersensitivity, a local inflammatory response of skin, was induced by spreading the back skin of NC/Nga mice with 0.4~1% DNCB. HRHDT was prepared by dissolving 3% HRHDT in solution and treated 3 weeks on the back skin.
Results: HRHDT significantly reduced TEWL and erythema by 0.4~1% of DNCB treatment compared to control group. HRHDT also reduced IgE on serum obtained from blood of DNCB-treated mice.
Conclusions: These results showed that HRHDT could be used as a pharmaceutical material with anti-atopic dermatitis effect by reducing IgE in contact hypersensitivity atopic dermatitis NC/Nga mice model by DNCB
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KEYWORD
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Hwangryunhaedok-tang, HRHDT, Atopic dermatitis, AD, NC/Nga mice, Transepidermal water Loss, DNCB, IgE
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